Title:Brain Delivery of Chemotherapeutics in Brain Cancer
Volume: 16
Issue: 2
Author(s): Bharat B. Subudhi and Vijay K. Singh
Affiliation:
Keywords:
Brain, chemotherapy, delivery, tumour.
Abstract: Treatment of brain tumour is a major challenge. This is mainly because of the limited bioavailability of
chemotherapeutics in the brain. The major hurdle for brain availability of anticancer agents is the blood brain
barrier (BBB). BBB is supposed to protect the brain and maintain homeostasis. It allows vital nutrient for normal
brain function and effluxes out foreign toxic substance. Advance in knowledge of bidirectional movement across
BBB has allowed development of strategies to enhance brain availability of chemotherapeutics for management of
brain tumour. In this review we have focussed on various approaches adopted for enhancing delivery of anticancer
agents. We have given a critical analysis of the approaches for further research