Title:Indole Derivatives as Anticancer Agents for Breast Cancer Therapy: A Review
Volume: 16
Issue: 2
Author(s): Jagpreet Singh Sidhu, Ramit Singla, Mayank and Vikas Jaitak
Affiliation:
Keywords:
Anticancer, apoptosis, breast cancer, indole, mTOR, resistance, signaling.
Abstract: Breast cancer (BC) is the second most common cause of cancer-related deaths in women throughout the
world. Multiple drugs have been approved by US-FDA for breast related malignancies. Frequent emergence of
resistances creates the severe need of newer moieties that are free from such problems. Drugs targeting breast
cancer have been observed to be based on the multiple mechanisms of action, and various indole based anticancer
agents have also been explored. Moreover, indoles have promising anti-cancer potential; there has been the
emphasis on the synthesis of indole derivatives to overcome problems faced by existing therapeutic agents. Taking
into consideration the above-mentioned facts we have analyzed in detail the possible role of indole based
anticancer agents typically for breast related malignancies. This is the first exhaustive review that jointly covers
various synthetic anticancer indole derivatives and related signaling pathways by which these derivatives have
shown promising anti-breast cancer potential.