![conference banner](/images/conference-banner.jpeg)
Abstract
Spasticity is a motor disorder with an increased muscle tone, typically associated with spasms, weakness and lack of coordination. It is an invalidating and debilitating pathology, characterized by pain, limited autonomy in activities of daily living, development of severe lesions. Spasticity can be adequately treated with physiotherapy, muscle relaxants drugs or topical treatment with botulinic toxin type A. Intrathecal baclofen therapy is very effective in the treatment of severe and generalized spasticity. Sometimes, soft tissues adjacent to the implant intrathecal infusion become infected; removing intrathecal infusion and systemic antibiotic therapy are best solution for clinical cure. However, removing intrathecal baclofen therapy could increase muscle spasticity with enhancement of pain and clonus that can worsen quality of life. In this study, we evaluated clinical improvement after complete healing of the septic focus and implantation of a new infuser
Keywords: Antibiotic therapy, baclofen, clonus, infection, intrathecal infusion, spasticity.
Endocrine, Metabolic & Immune Disorders - Drug Targets
Title:Use Of External Intrathecal Infusion Pumps In The Management Of Septic Complications: A Case Report
Volume: 15 Issue: 4
Author(s): Riccardo Marvulli, Pierpaolo Chiumarulo, Mattia Nisi, Laura Barulli, Gianfranco Megna, Fiore Pietro, Giancarlo Ianieri and Marisa Megna
Affiliation:
Keywords: Antibiotic therapy, baclofen, clonus, infection, intrathecal infusion, spasticity.
Abstract: Spasticity is a motor disorder with an increased muscle tone, typically associated with spasms, weakness and lack of coordination. It is an invalidating and debilitating pathology, characterized by pain, limited autonomy in activities of daily living, development of severe lesions. Spasticity can be adequately treated with physiotherapy, muscle relaxants drugs or topical treatment with botulinic toxin type A. Intrathecal baclofen therapy is very effective in the treatment of severe and generalized spasticity. Sometimes, soft tissues adjacent to the implant intrathecal infusion become infected; removing intrathecal infusion and systemic antibiotic therapy are best solution for clinical cure. However, removing intrathecal baclofen therapy could increase muscle spasticity with enhancement of pain and clonus that can worsen quality of life. In this study, we evaluated clinical improvement after complete healing of the septic focus and implantation of a new infuser
Export Options
About this article
Cite this article as:
Marvulli Riccardo, Chiumarulo Pierpaolo, Nisi Mattia, Barulli Laura, Megna Gianfranco, Pietro Fiore, Ianieri Giancarlo and Megna Marisa, Use Of External Intrathecal Infusion Pumps In The Management Of Septic Complications: A Case Report, Endocrine, Metabolic & Immune Disorders - Drug Targets 2015; 15 (4) . https://dx.doi.org/10.2174/1871530315666150506124127
DOI https://dx.doi.org/10.2174/1871530315666150506124127 |
Print ISSN 1871-5303 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3873 |
Call for Papers in Thematic Issues
Chronic inflammation and Disorders/Cancers
Chronic inflammation is fundamental cause of variety of disorders. Many lifestyle-related diseases including metabolic syndrome, obesity, impairment of immune responses, sepsis, mental illness, and other disorders are caused by chronic inflammation. Prevention of chronic inflammation is related to antiaging effects of our body. Proinflammatory cytokines such as TNF-α is associated ...read more
Immune defense of the blood-tissue barriers which are related to drugs, metabolic and hormones
We have already known that testis is an immune privilege area for the maintenance of spermatogenesis against to any pathogen from the interstitial area. With the BTB integrity there is a qualified selection for the mature sperm until the lumen migration which is sperm release progress. Spermiogenesis help for the ...read more
![Wayfinder Image](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Brain Delivery Systems via Mechanism Independent of Receptor-Mediated Endocytosis and Adsorptive-Mediated Endocytosis
Current Pharmaceutical Biotechnology Peptide Mediated Brain Delivery of Nano- and Submicroparticles: A Synergistic Approach
Current Pharmaceutical Design Nanotechnology in Neuroscience and its Perspective as Gene Carrier
Current Topics in Medicinal Chemistry How Do Abnormalities in the Cerebrospinal Fluid Impact Neuropsychology with Progressing Age?
CNS & Neurological Disorders - Drug Targets Intranasal Fluorescent Nanocrystals for Longitudinal <i>In Vivo</i> Evaluation of Cerebral Microlesions
Pharmaceutical Nanotechnology G-Lymphatic, Vascular and Immune Pathways for Aβ Clearance Cascade and Therapeutic Targets For Alzheimer’s Disease
Combinatorial Chemistry & High Throughput Screening Protection of Blood Brain Barrier Integrity and Modulation of Inflammatory Mediators During Treatment of Pneumococcal Meningitis with Daptomycin or Ceftriaxone
Current Neurovascular Research The Updated Role of the Blood Brain Barrier in Subarachnoid Hemorrhage: From Basic and Clinical Studies
Current Neuropharmacology <i>In-vitro</i> and <i>In-silico</i> Examinations on Baicalein-loaded Solid Lipid Nanoparticles for Neurodegeneration
Drug Delivery Letters Small Neuroscience: The Nanostructure of the Central Nervous System and Emerging Nanotechnology Applications
Current Nanoscience Protection Mechanisms Against Aβ42 Aggregation
Current Alzheimer Research Coexistence of Large Meningioma and Arteriovenous Malformation: A Case Report and Literature Review
Current Medical Imaging Gene Therapy of Chronic Pain
Current Gene Therapy Expression and Function of Organic Cation and Anion Transporters (SLC22 Family) in the CNS
Current Pharmaceutical Design Drug Delivery to CNS: Challenges and Opportunities with Emphasis on Biomaterials Based Drug Delivery Strategies
Current Pharmaceutical Design Inherited Renal Diseases
Current Pediatric Reviews Neonatal Brain Hemorrhage (NBH) of Prematurity: Translational Mechanisms of the Vascular-Neural Network
Current Medicinal Chemistry Deciphering the Physiology Underlying the Rapid Clinical Effects of Perispinal Etanercept in Alzheimers Disease
Current Alzheimer Research Biomarkers for Alzheimer’s Disease
Current Alzheimer Research Artificial Intelligence for Epigenetics: Towards Personalized Medicine
Current Medicinal Chemistry