Cysteine and Its Derivatives as New Delhi Metallo-beta-lactamase-1 Inhibitors

Title:Cysteine and Its Derivatives as New Delhi Metallo-beta-lactamase-1 Inhibitors

Volume: 11 Issue: 1

Author(s): Cui-Gai Bai, Yin-Tong Xu, Ning-Ning Li, Jing-Han Wang, Cheng Yang, Yue Chen and Hong-Gang Zhou

Affiliation:

Keywords: IC50, NDM-1, cysteine, captopril, derivatives, inhibition.

Abstract: Nearly all antibiotics are ineffective to the antibiotic-resistant bacteria New Delhi metallo-beta -lactamase-1(NDM-1), one of the most important reasons is that antibiotics can be hydrolyzed by NDM-1 in these bacteria. Up to date, Many compounds, including captopril, are found to possess NDM-1 inhibition activity. Herein we report that some cysteine derivatives or homocysteine derivatives can inhibit the NDM-1 protein, and the lead compound 9 has the inhibition of the NDM-1 protein with IC₅₀ of 1 µM, which is about 8 times potency of captopril.

Cite this article as:

Bai Cui-Gai, Xu Yin-Tong, Li Ning-Ning, Wang Jing-Han, Yang Cheng, Chen Yue and Zhou Hong-Gang, Cysteine and Its Derivatives as New Delhi Metallo-beta-lactamase-1 Inhibitors, Current Enzyme Inhibition 2015; 11 (1) . https://dx.doi.org/10.2174/1573408011666150408223245