Generic placeholder image

Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Biological Agents in Familial Mediterranean Fever Focusing on Colchicine Resistance and Amyloidosis

Author(s): Betul Sozeri and Ozgur Kasapcopur

Volume 22, Issue 16, 2015

Page: [1986 - 1991] Pages: 6

DOI: 10.2174/0929867322666150311152300

Price: $65

conference banner
Abstract

Familial Mediterranean fever (FMF) is the most common hereditary autoinflammatory syndrome. FMF is caused by mutations in the MEFV gene which encodes the pyrin protein. FMF is characterized by sporadic, paroxysmal attacks of fever and serosal inflammation, lasting 1-3 days. Patients may develop renal amyloidosis. Colchicine prevents attacks and renal amyloidosis.5% to 10% of the patients with FMF are resistant or intolerant to colchicine. Colchicine resistant patients may receive biological therapies. Anti-interleukin-1 drugs are the most important agents of biological treatments. In this review, colchicine resistance and treatment options will be evaluated.

Keywords: Colchicine resistance, Familial Mediterranean fever, therapy.


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy