Title:Synthesis and Biological Activity of N-Aminoethyl-terpinene-maleimidebased Thiourea Compounds
Volume: 12
Issue: 4
Author(s): Lu-zhi Liu, Jing-ni Liao, Wen-gui Duan, Gui-shan Lin and Fu-hou Lei
Affiliation:
Keywords:
α-pinene, α-terpinene-maleic anhydride, fungicidal activity, herbicidal activity, thioureas and synthesis.
Abstract: In search of novel potent bioactive compounds, a series of novel maleimide-based thiourea
derivatives containing terpinene structure were designed and synthesized. Their structures were characterized
by IR, MS, NMR, UV-vis and elemental analysis. The preliminary bioassay showed that the
target compounds exhibited a certain fungicidal activity, in which compound 2-methoxyphenyl-Naminoethyl-
terpinene-maleimide-based thiourea 5h exhibited the best inhibitory ratio of 64.2%
against Alternaria solani at the concentration of 50 μg•mL-1. A few of the target compounds showed a certain growth inhibition
activity against rape root (Brassica campestris), in which compound 5h exhibited the best inhibitory ratio of
82.0% (A-class activity level) at the concentration of 100 μg•mL-1. The intermediate 4 exhibited excellent growth inhibitory
ratio of 92.3% (A-class activity level) against rape root at the concentration of 100 μg•mL-1. In addition, the structureantifungal
activity relationship of these compounds was also discussed.
