Title:Natural Organic Acids Promoted Synthesis of 3, 4-Dihydropyrimidin- 2(1H)-ones/thiones Under Solvent-free Conditions
Volume: 12
Issue: 3
Author(s): Nitin M. Thorat and Shankar R. Thopate
Affiliation:
Keywords:
Biginelli reaction, 3, 4-dihydropyrimidin-2(1H)-ones/thiones, naturally occurring acid, green promoters, solventfree
synthesis.
Abstract: Naturally occurring organic acids are reported to be highly efficient promoters for the Biginelli reaction under
thermal and microwave irradiation using solvent free conditions. Among the various organic acids used, malic acid was
found to be the most effective promoter for Biginelli reaction under above reaction conditions. Present protocol is a simple
and eco-friendly route for the synthesis of 3, 4-dihydropyrimidin-2(1H)-ones/thiones.
