Title:Safety and Efficacy of Intracoronary Human Umbilical Cord-Derived Mesenchymal Stem Cell Treatment for Very Old Patients with Coronary Chronic Total Occlusion
Volume: 21
Issue: 11
Author(s): Xia Li, You-dong Hu, Yan Guo, Ying Chen, Dian-xuan Guo, Hua-lan Zhou, Feng-lin Zhang and Qing-na Zhao
Affiliation:
Keywords:
Chronic myocardial ischemia, elderly, human umbilical cord-derived mesenchymal stem cells, therapy.
Abstract: This study aimed to investigate the safety and feasibility of intracoronary injection of human umbilical cord
mesenchymal stem cell to the very old patients with coronary chronic total occlusion. 15 consecutive patients received
mesenchymal stem cells from human umbilical cord in epicardial coronary artery supplying collateral circulation. The patients
were randomly allocated to low-dose 3x106, mid-dose 4x106 and high-dose 5x106 groups. 99mTc single photon emission
computed tomography images were obtained at 12 and 24 months. During the 24 month study period, no cases of major
cardiac adverse events were reported. None of the patients had coronary care unit admissionshospitalizationsfurther
coronary revascularizationacute myocardial infarction and death. The patients had a significant reduction of the infarct size
and a remarkable rise in left ventricular ejection fraction with respect to secondary outcomes. This study suggested that
stem cell transplantation was safe and feasible. The cells can be utilized to improve in the degree of ischemic myocardium, decrease in
the infarct size and rise in left ventricular ejection fraction.
