Title:Oxidative Stress and Post-Stroke Depression: Possible Therapeutic Role of Polyphenols?
Volume: 22
Issue: 3
Author(s): Seyed Fazel Nabavi, Olivia M. Dean, Alyna Turner, Antoni Sureda, Maria Daglia and Seyed Mohammad Nabavi
Affiliation:
Keywords:
Major depressive disorder, oxidative stress, polyphenols, post-stroke depression, stroke.
Abstract: Post-stroke depression is a common neuropsychiatric affective disorder that may develop after a stroke event.
In addition to abnormalities in the biogenic amine neurotransmitters and cytokine expression induced by stroke we will
focus on the role of oxidative stress and hypothesize that polyphenols may be useful as therapeutics targets for the treatment
of post-stroke depression. In this paper, we discuss the hypothesis that increased oxidative stress in cerebral tissues
during ischemia is implicated in the pathogenesis of depressive-like symptoms following stroke. There is substantive evidence
regarding the role of oxidative stress in the pathogenesis of both stroke and depression, which provides support to
this hypothesis. Reactive oxygen species, generated during stroke, cause oxidative stress, lipid peroxidation, protein oxidation,
and DNA damage in neural tissues. The resultant pathophysiological processes in the neural tissues could be considered
a leading mechanism in the induction of post-stroke depression. Antioxidants including polyphenols therefore,
may play an important role in the outcomes of ischemia and stroke, due to their ability to protect neurons against oxidative
stress, to mitigate ischemic damage via inhibition of lipid peroxidation and ability to interact with the generation of nitric
oxide from the vascular endothelium, and also to decrease inflammation. These data suggest that polyphenols may therefore
be a useful new therapeutic target for the treatment of post-stroke depression.
