Title:P2X Receptors and Diabetes
Volume: 22
Issue: 7
Author(s): Carmen Fotino, Andrea Vergani, Paolo Fiorina and Antonello Pileggi
Affiliation:
关键词:
β细胞，糖尿病，细胞外ATP ，炎症，胰岛，胰岛免疫，代谢综合征，嘌呤能受体， P2X ，1型糖尿病，2型糖尿病。
摘要: Diabetes is a metabolic disorder characterized by elevation of glucose levels in the blood that develops in humans
as a result of genetic predisposition and environmental factors. Unbalanced glycemic control has been associated
with the development of progressive and debilitating complications that dramatically affect the quality of life and life expectancy
of people with diabetes. The purinergic system represents a widely diffused signaling pathway in mammalian
cells of different tissues where it plays critical roles in both physiological and pathological conditions. Herein we review
the increasing evidence supporting that the purinergic system plays an important role in the multiple facets of diabetes, including
its physiopathology and complications. We also discuss the potential relevance of the purinergic pathway for diagnosis
and treatment of diabetes.
