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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Structure-Function Correlations of Snake Venom Disintegrins&#

Author(s): Juan J. Calvete

Volume 11, Issue 7, 2005

Page: [829 - 835] Pages: 7

DOI: 10.2174/1381612053381783

Price: $65

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Abstract

Disintegrins represent a family of polypeptides released in the venoms of Viperidae and Crotalidae snakes (vipers and rattlesnakes) by the proteolytic processing of multidomain metalloproteinases, which selectively block the function of β1 and β3 integrin receptors. Research on disintegrins is relevant for understanding the biology of viper venom toxins, but also provides information of new structural determinants involved in integrin recognition that may be useful in both, basic and clinical research. The role of the composition, conformation and concerted dynamics of the integrin inhibitory loop and the C-terminal tail in determining the selective inhibition of integrin receptors is discussed.

Keywords: crotalidae snakes, hemorrhage, metalloproteinases, integrin-ligand interactions, svmps molecules


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