体质指数、脂类代谢和雌激素：他们对冠心病的影响

Title:Body Mass Index, Lipid Metabolism and Estrogens: Their Impact on Coronary Heart Disease

Volume: 21 Issue: 30

Author(s): G.D. Kolovou, V. Kolovou, P.M. Kostakou and S. Mavrogeni

Affiliation:

关键词: 体脂肪，冠心病，激素替代疗法，脂类，更年期。

摘要: Estrogens influence lipid metabolism and body fat distribution in women. Premenopausal women have increased lipoprotein lipase action in abdominal and femoral subcutaneous fat compared with men of the same age. Estrogens may also affect adipose tissue either directly through specific estrogen receptors or indirectly via their effects on other tissues. As adipose tissue produces several cytokines including leptin, adiponectin and interleukin-6, estrogens may alter their levels, thus influencing various biological processes. Lack of estrogens such as in menopause, causes an increase in visceral adiposity, leading to changes in lipid and lipoprotein metabolism. Due to those alterations, postmenopausal women are more prone to coronary heart disease. In this review the influence of estrogens on body mass index, lipid metabolism and some of the therapeutic options will be analyzed.

Cite this article as:

Kolovou G.D., Kolovou V., Kostakou P.M. and Mavrogeni S., Body Mass Index, Lipid Metabolism and Estrogens: Their Impact on Coronary Heart Disease, Current Medicinal Chemistry 2014; 21 (30) . https://dx.doi.org/10.2174/0929867321666140901114515