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摘要
雌激素可以影响女性的脂类代谢和体脂分布。与同龄的男性相比,绝经前期的女性已经增强了腹部和股骨皮下脂肪的脂蛋白酯酶作用。雌激素还可以直接通过特异性雌激素受体影响脂肪组织,或者间接地影响其它组织。由于脂肪组织产生数种细胞因子,包括瘦素、脂联素和白细胞介素-6,雌激素也许可以改变他们的水平,从而影响各种各样的生物进程。如在更年期雌激素缺乏,可以引起腹部肥胖的增加,导致脂质和脂蛋白代谢的改变。由于这些改变,绝经后的女性更易于患有冠心病。本综述将分析归纳雌激素对体质指数 、脂类代谢和一些治疗方式的影响。
关键词: 体脂肪,冠心病,激素替代疗法,脂类,更年期。
Current Medicinal Chemistry
Title:Body Mass Index, Lipid Metabolism and Estrogens: Their Impact on Coronary Heart Disease
Volume: 21 Issue: 30
Author(s): G.D. Kolovou, V. Kolovou, P.M. Kostakou and S. Mavrogeni
Affiliation:
关键词: 体脂肪,冠心病,激素替代疗法,脂类,更年期。
摘要: Estrogens influence lipid metabolism and body fat distribution in women. Premenopausal women have increased lipoprotein lipase action in abdominal and femoral subcutaneous fat compared with men of the same age. Estrogens may also affect adipose tissue either directly through specific estrogen receptors or indirectly via their effects on other tissues. As adipose tissue produces several cytokines including leptin, adiponectin and interleukin-6, estrogens may alter their levels, thus influencing various biological processes. Lack of estrogens such as in menopause, causes an increase in visceral adiposity, leading to changes in lipid and lipoprotein metabolism. Due to those alterations, postmenopausal women are more prone to coronary heart disease. In this review the influence of estrogens on body mass index, lipid metabolism and some of the therapeutic options will be analyzed.
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Cite this article as:
Kolovou G.D., Kolovou V., Kostakou P.M. and Mavrogeni S., Body Mass Index, Lipid Metabolism and Estrogens: Their Impact on Coronary Heart Disease, Current Medicinal Chemistry 2014; 21 (30) . https://dx.doi.org/10.2174/0929867321666140901114515
DOI https://dx.doi.org/10.2174/0929867321666140901114515 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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