Abstract
Estrogens influence lipid metabolism and body fat distribution in women. Premenopausal women have increased lipoprotein lipase action in abdominal and femoral subcutaneous fat compared with men of the same age. Estrogens may also affect adipose tissue either directly through specific estrogen receptors or indirectly via their effects on other tissues. As adipose tissue produces several cytokines including leptin, adiponectin and interleukin-6, estrogens may alter their levels, thus influencing various biological processes. Lack of estrogens such as in menopause, causes an increase in visceral adiposity, leading to changes in lipid and lipoprotein metabolism. Due to those alterations, postmenopausal women are more prone to coronary heart disease. In this review the influence of estrogens on body mass index, lipid metabolism and some of the therapeutic options will be analyzed.
Keywords: Body fat, coronary heart disease, estrogens, hormone replacement therapy, lipids, menopause.
Current Medicinal Chemistry
Title:Body Mass Index, Lipid Metabolism and Estrogens: Their Impact on Coronary Heart Disease
Volume: 21 Issue: 30
Author(s): G.D. Kolovou, V. Kolovou, P.M. Kostakou and S. Mavrogeni
Affiliation:
Keywords: Body fat, coronary heart disease, estrogens, hormone replacement therapy, lipids, menopause.
Abstract: Estrogens influence lipid metabolism and body fat distribution in women. Premenopausal women have increased lipoprotein lipase action in abdominal and femoral subcutaneous fat compared with men of the same age. Estrogens may also affect adipose tissue either directly through specific estrogen receptors or indirectly via their effects on other tissues. As adipose tissue produces several cytokines including leptin, adiponectin and interleukin-6, estrogens may alter their levels, thus influencing various biological processes. Lack of estrogens such as in menopause, causes an increase in visceral adiposity, leading to changes in lipid and lipoprotein metabolism. Due to those alterations, postmenopausal women are more prone to coronary heart disease. In this review the influence of estrogens on body mass index, lipid metabolism and some of the therapeutic options will be analyzed.
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Cite this article as:
Kolovou G.D., Kolovou V., Kostakou P.M. and Mavrogeni S., Body Mass Index, Lipid Metabolism and Estrogens: Their Impact on Coronary Heart Disease, Current Medicinal Chemistry 2014; 21 (30) . https://dx.doi.org/10.2174/0929867321666140901114515
DOI https://dx.doi.org/10.2174/0929867321666140901114515 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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