Title:A Comprehensive Review of Poorly Differentiated Neuroendocrine Carcinomas (pdNECs): a Niche to Find Novel Opportunities
Volume: 20
Issue: 42
Author(s): Pablo Reguera, Ainhoa Madariaga and Enrique Grande
Affiliation:
Keywords:
Management, neuroendocrine tumors, poorly-differentiated, review.
Abstract: Although grouped under the same name, neuroendocrine tumors comprise a heterogeneous family of neoplasms with a wide
range of clinical and biological behaviors and responses to different treatment options. Most of the tumors derived from enterochromaffin
cells are indolent or at least not as aggressive as epithelial tumors. However, a small percentage of these tumors have a poor prognosis
and highly aggressive histology that results in a very short overall survival and scarce treatment options compared with well and moderately
differentiated tumors. Patients with poorly differentiated neuroendocrine carcinomas barely exceed 6-8 months of survival. This
particular poor risk subgroup of neuroendocrine tumors remains an unmet medical need and becomes a challenge in the daily clinical
practice. A deeper knowledge of the biology and novel targeted agents might allow for future clinical development of novel agents in this
setting. In this review we summarize the current background behind the management of poorly differentiated neuroendocrine carcinomas
in daily clinical practice.
