Title:Anti-Metastatics: An Overview of Drug Candidates in Current Pipelines
Volume: 20
Issue: 42
Author(s): Anne Schaap-Nutt, Dane A. Thyssen, David W. Drell and Frank Entschladen
Affiliation:
Keywords:
Metastasis, invasion, cell migration, signal transduction.
Abstract: As the number of novel drugs that have entered the market in oncology has slowed in recent years, there has been a dramatic
shift towards new therapeutic approaches. The majority of cancer patients die from metastasis formation, which has prompted the pharmaceutical
industry to begin to investigate a new class of agents: anti-metastatics. This review provides an overview of the targets,
mechanisms of action, and drug substances currently in the pharma pipeline to inhibit tumor cell migration and metastasis formation.