Title:Targeting the Mannose Receptor with Mannosylated Subunit Vaccines
Volume: 21
Issue: 30
Author(s): B. Sedaghat, R. Stephenson and I. Toth
Affiliation:
关键词:
树突细胞，糖基，甘露糖，甘露糖受体，多肽疫苗，靶向。
摘要: The mannose receptor (MR) is an important component of the immune system and understanding the structural
and conformational characteristics of this receptor is a key aspect of vaccine design. Improved understanding of the role
of carbohydrate recognition domains 4-7 (CRDs 4-7) in recognising glycosylated ligands present on the surface of pathogens
such as C.albicans, P. carinii, L. donovani, and M. tuberculosis has given new insight into MR vaccine development.
Initial studies identified mannan and its derivatives to be important ligands in MR targeting, providing essential knowledge
about the MR structural properties. The MR was found to be an early responder in immunogenic pathways. Many attempts
have been made to mimic the structural properties of yeast mannan by attaching mannan or mannose to antigenic
proteins or peptide epitopes. However, a more detailed understanding of the structural properties of the MR is necessary
for the design of targeted vaccines. This review describes the structure of the MR and provides an overview of the use of
mannosylated proteins and peptides for vaccine targeting.
