Title:Nanomedicine Based Nanoparticles for Neurological Disorders
Volume: 21
Issue: 36
Author(s): Bhasker Sriramoju, Rupinder K. Kanwar and Jagat R. Kanwar
Affiliation:
Keywords:
Blood brain barrier, nanomedicine, neurological disorders, polymeric nanoparticles, targeted therapeutics.
Abstract: Human health is severely hampered by a majority of the neurological disorders such as the brain tumors, degenerative
Alzheimer’s disease, Parkinson’s disease and those involving inflammatory component. Owing to the stringent
protection offered by the blood brain barrier, conventional therapeutics gain limited access and therefore, are therapeutically
suboptimal. Hence, research has now focused to develop the novel drug delivery systems with a prime motto of
maintaining therapeutic drug levels inside the brain, avoiding non-specific tissue distribution. The introduction of
nanotechnology has addressed few of these objectives and opened up new avenues for even more improvization. To some
extent, nanodelivery systems were successful in crossing the blood brain barrier and accessing the remote areas of the
brain. They also have shown tremendous potential in delivering the therapeutic and diagnostic aids following systemic
administration. What revolutionised the nano applications is the development of “smart” nanosystems, whose surface is
tailor made for the effective theranostic delivery. However, a detailed understanding of the long term nanoformulation
toxicities, along with the neuropathology, is the critical future question to be addressed. In this review, a brief introduction
of the prominent neurological disorders and detailed applications of nanotechnology are discussed.
