Abstract
Early postpartum hemorrhage remains a significant cause of maternal morbidity and mortality. Postpartum hemorrhage is most commonly due to uterine atony and often responds to medical treatments such as administration of uterotonic drugs, alone or in combination with uterine massage or bimanual compression. As the incidence of cesarean section continues to rise, the problem of placenta previa and accreta is likely to become more common. For first-line management of postpartum hemorrhage adequate blood and fluid replacement is mandatory. In recent years new therapeutic measures to control the bleeding have gained attention. Although, these newer therapies focus on avoiding the need for emergency hysterectomy and preservation of reproductive function, reports of subsequent pregnancies are still scarce. Established management options are shortly reviewed and novel medical and surgical treatments are more extensively discussed.
Keywords: postpartum hemorrhage, atony, recombinant activated factor VII, tranexamic acid
Current Pharmaceutical Design
Title: Pharmacological and Surgical Therapy for Primary Postpartum Hemorrhage
Volume: 11 Issue: 6
Author(s): F. W. Bouwmeester, A. C. Bolte and H. P. van Geijn
Affiliation:
Keywords: postpartum hemorrhage, atony, recombinant activated factor VII, tranexamic acid
Abstract: Early postpartum hemorrhage remains a significant cause of maternal morbidity and mortality. Postpartum hemorrhage is most commonly due to uterine atony and often responds to medical treatments such as administration of uterotonic drugs, alone or in combination with uterine massage or bimanual compression. As the incidence of cesarean section continues to rise, the problem of placenta previa and accreta is likely to become more common. For first-line management of postpartum hemorrhage adequate blood and fluid replacement is mandatory. In recent years new therapeutic measures to control the bleeding have gained attention. Although, these newer therapies focus on avoiding the need for emergency hysterectomy and preservation of reproductive function, reports of subsequent pregnancies are still scarce. Established management options are shortly reviewed and novel medical and surgical treatments are more extensively discussed.
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Cite this article as:
Bouwmeester W. F., Bolte C. A. and van Geijn P. H., Pharmacological and Surgical Therapy for Primary Postpartum Hemorrhage, Current Pharmaceutical Design 2005; 11 (6) . https://dx.doi.org/10.2174/1381612053381882
DOI https://dx.doi.org/10.2174/1381612053381882 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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