Title:Impact of MCP -1 in Atherosclerosis
Volume: 20
Issue: 28
Author(s): Juntang Lin, Vijay Kakkar and Xinjie Lu
Affiliation:
Keywords:
MCP-1, CCL2, CCLR2, atherosclerosis and chemokine.
Abstract: Monocyte chemotactic protein-1 (MCP-1) (also referred to as chemokine (C-C motif) ligand 2 (CCL2) is expressed by mainly
inflammatory cells and endothelial cells. The expression level is upregulated after proinflammatory stimuli and tissue injury which are
associated with atherosclerotic lesion. Atherosclerosis is a progressive disease starting with accumulation of lipids, lipoproteins, and immune
cells in the arterial wall. MCP-1 has been reported to play an important role in the pathogenesis of atherosclerosis and considerable
evidence supports that the monocyte containing MCPs and macrophage influences the growth of other cell types within the atherosclerotic
lesion. This review will focus on the general structure features of MCP-1 and its role in atherosclerosis.
