Title:4'-Modified Pyrimidine Nucleosides as Potential Anti-hepatitis C Virus (HCV) Agents
Volume: 11
Issue: 7
Author(s): Neeraj Shakya, Satish Vedi, Chao Liang, Babita Agrawal and Rakesh Kumar
Affiliation:
Keywords:
Hepatitis C virus, Anti-HCV effect, Synthesis, Nucleosides.
Abstract: Herein, we have investigated novel pyrimidine nucleosides bearing a 4’-carboxyl functionality (6-10, 13 and
15) as anti-HCV agents. In this new class of compounds, 7, 9, 10 and 15 demonstrated in vitro anti-HCV activity similar
to or better than a known anti-HCV drug, ribavirin. In this work, we also, surprisingly, identified a 3’-sulfoxide analog of
3’-thiacytidine (16), obtained as a side product during the synthesis of 15, as a potent inhibitor of HCV replication at the
concentration similar to that of ribavirin. No detectable in vitro cytotoxicity was observed for the investigated compounds
up to the highest concentration tested.
