Title:Modifying Anti-Inflammatory Effect of Diclofenac with Murraya koenigii
Volume: 8
Issue: 1
Author(s): Ginpreet Kaur, Saloni Daftardar and Kalyani H. Barve
Affiliation:
Keywords:
Anti-inflammatory activity, medicinal plants, Murraya koenigii, pharmacodynamic interactions, synthetic drug.
Abstract: Murraya koenigii (Curry leaves) has been widely used in Asian countries for the treatment of some ailments
such as diabetes and hypertension. In the present study, leaves of Murraya koenigii were extracted with ethanol and
evaluated for anti-inflammatory activity in rats using carrageenan induced paw edema method. Ethanolic extract showed a
potent anti-inflammatory activity at third hour after carrageenan administration when compared with the standard drug,
Diclofenac. The percent inhibition of paw volume was found to be 84.75% for 50 mg/kg of extract whereas it was found
to be 80.86% for 50 mg/kg extract in combination with Diclofenac 10 mg/kg. Thus, the present study suggests that the
combination therapy potentiates the anti-inflammatory effect of diclofenac and may help in reducing the dose of the synthetic
drug. Some relevant patents are also outlined in this article.
