Abstract
Dehydroacetic acid (DHA) and its simple derivatives find many interesting applications in the synthesis of various heterocyclic compounds of potential biological interest. A variety of DHA based chemical reactions were found to be useful in the synthesis of 3-cinnamoyl-4-hydroxy-6-methyl-2-oxo-2H-pyrans i.e. Chalcone analogues of DHA, pyranopyrazoles, substituted pyrones, 2H-Pyran and 2H-pyridine-2-ones, pyrimidines, pyrazoles, thiazoles, and pyridazines etc. The present review focuses on the synthetic and biological potential of DHA and provides update on the literature survey upto 2013.
Keywords: Biological activity, Dehydroacetic acid, Heterocycle, Synthetic method.
Letters in Organic Chemistry
Title:DHA: An Excellent Source of Bioactive Heterocycles
Volume: 11 Issue: 4
Author(s): Girish Kumar Gupta, Ankit Mittal and Vinod Kumar
Affiliation:
Keywords: Biological activity, Dehydroacetic acid, Heterocycle, Synthetic method.
Abstract: Dehydroacetic acid (DHA) and its simple derivatives find many interesting applications in the synthesis of various heterocyclic compounds of potential biological interest. A variety of DHA based chemical reactions were found to be useful in the synthesis of 3-cinnamoyl-4-hydroxy-6-methyl-2-oxo-2H-pyrans i.e. Chalcone analogues of DHA, pyranopyrazoles, substituted pyrones, 2H-Pyran and 2H-pyridine-2-ones, pyrimidines, pyrazoles, thiazoles, and pyridazines etc. The present review focuses on the synthetic and biological potential of DHA and provides update on the literature survey upto 2013.
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Cite this article as:
Gupta Kumar Girish, Mittal Ankit and Kumar Vinod, DHA: An Excellent Source of Bioactive Heterocycles, Letters in Organic Chemistry 2014; 11 (4) . https://dx.doi.org/10.2174/1570178610666131230235759
DOI https://dx.doi.org/10.2174/1570178610666131230235759 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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