Abstract
Dehydroacetic acid (DHA) and its simple derivatives find many interesting applications in the synthesis of various heterocyclic compounds of potential biological interest. A variety of DHA based chemical reactions were found to be useful in the synthesis of 3-cinnamoyl-4-hydroxy-6-methyl-2-oxo-2H-pyrans i.e. Chalcone analogues of DHA, pyranopyrazoles, substituted pyrones, 2H-Pyran and 2H-pyridine-2-ones, pyrimidines, pyrazoles, thiazoles, and pyridazines etc. The present review focuses on the synthetic and biological potential of DHA and provides update on the literature survey upto 2013.
Keywords: Biological activity, Dehydroacetic acid, Heterocycle, Synthetic method.
Letters in Organic Chemistry
Title:DHA: An Excellent Source of Bioactive Heterocycles
Volume: 11 Issue: 4
Author(s): Girish Kumar Gupta, Ankit Mittal and Vinod Kumar
Affiliation:
Keywords: Biological activity, Dehydroacetic acid, Heterocycle, Synthetic method.
Abstract: Dehydroacetic acid (DHA) and its simple derivatives find many interesting applications in the synthesis of various heterocyclic compounds of potential biological interest. A variety of DHA based chemical reactions were found to be useful in the synthesis of 3-cinnamoyl-4-hydroxy-6-methyl-2-oxo-2H-pyrans i.e. Chalcone analogues of DHA, pyranopyrazoles, substituted pyrones, 2H-Pyran and 2H-pyridine-2-ones, pyrimidines, pyrazoles, thiazoles, and pyridazines etc. The present review focuses on the synthetic and biological potential of DHA and provides update on the literature survey upto 2013.
Export Options
About this article
Cite this article as:
Gupta Kumar Girish, Mittal Ankit and Kumar Vinod, DHA: An Excellent Source of Bioactive Heterocycles, Letters in Organic Chemistry 2014; 11 (4) . https://dx.doi.org/10.2174/1570178610666131230235759
DOI https://dx.doi.org/10.2174/1570178610666131230235759 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
![](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Interrelation of Major Depression and Antidepressant Transcriptomics
Current Psychopharmacology Quality, not Quantity: The Role of Natural Products and Chemical Proteomics in Modern Drug Discovery
Combinatorial Chemistry & High Throughput Screening The Contribution of Proteinase-Activated Receptors to Intracellular Signaling, Transcellular Transport and Autophagy in Alzheimer´s Disease
Current Alzheimer Research Natural Marine Anti-inflammatory Products
Mini-Reviews in Medicinal Chemistry Radiation-Induced Neuroinflammation and Radiation Somnolence Syndrome
CNS & Neurological Disorders - Drug Targets Can Tea Consumption be a Safe and Effective Therapy Against Diabetes Mellitus-Induced Neurodegeneration?
Current Neuropharmacology The Role of Pericytes in Neurovascular Unit: Emphasis on Stroke
Current Drug Targets Radiolabeled RGD Peptides as Integrin alpha(v)beta3–targeted PET Tracers
Current Medicinal Chemistry Curcuminoids as Cell Signaling Pathway Modulators: A Potential Strategy for Cancer Prevention
Current Medicinal Chemistry Nanoparticle-Based Gene Therapy Intervention for Stroke Treatment: A Systematic Review
Current Gene Therapy Cardiotoxicity of Molecularly Targeted Agents
Current Cardiology Reviews Leptin and Interleukin-1β Modulate Neuronal Glutamate Release and Protect Against Glucose-Oxygen-Serum Deprivation
Current Neurovascular Research Monocyclic and Fused Azines and Azoles as Histamine H<sub>4</sub> Receptor Ligands
Current Medicinal Chemistry Safety and Monitoring of the Treatment with Disease-Modifying Therapies (DMTs) for Multiple Sclerosis (MS)
Current Reviews in Clinical and Experimental Pharmacology Hypertension to Heart Failure: New Developmental Strategies do not Cross a Clinical and Therapeutic Divide
Current Pharmaceutical Design Immunotoxins and Other Conjugates: Pre-clinical Studies
Mini-Reviews in Medicinal Chemistry Patent Selections
Recent Patents on Nanotechnology Commentary 2 (The Contribution of Glial Cells and Water Channel Aquaporin-4 in the Neuropathology of Cardiac Arrest is Still Ignored)
CNS & Neurological Disorders - Drug Targets Conference Report
CNS & Neurological Disorders - Drug Targets Regulation of Adrenomedullin and its Family Peptide by RAMP System – Lessons from Genetically Engineered Mice
Current Protein & Peptide Science