A Xylose-Catalyzed One-Pot Four-Component Domino Protocol for the Facile Synthesis of Highly Substituted Dihydropyrrol-2-ones

Title:A Xylose-Catalyzed One-Pot Four-Component Domino Protocol for the Facile Synthesis of Highly Substituted Dihydropyrrol-2-ones

Volume: 11 Issue: 4

Author(s): Seyed Sajad Sajadikhah, Malek Taher Maghsoodlou, Nourallah Hazeri, Maryam Moein, Mahmoud Norouzi and Sajad Mohamadian-Souri

Affiliation:

Keywords: Dihydropyrrol-2-one, heterocycle, xylose, organocatalyst, multi-component reaction.

Abstract: Xylose was found as a natural, cheap and efficient organocatalyst for the one-pot synthesis of substituted dihydropyrrol- 2-ones via a four-component domino reaction between amines, dialkyl acetylenedicarboxilates and formaldehyde. This protocol includes some important aspects like mild reaction conditions, good yields, short reaction times, affordable procedure, simple work-up and lack of need for column chromatography.

Cite this article as:

Sajadikhah Sajad Seyed, Maghsoodlou Taher Malek, Hazeri Nourallah, Moein Maryam, Norouzi Mahmoud and Mohamadian-Souri Sajad, A Xylose-Catalyzed One-Pot Four-Component Domino Protocol for the Facile Synthesis of Highly Substituted Dihydropyrrol-2-ones, Letters in Organic Chemistry 2014; 11 (4) . https://dx.doi.org/10.2174/1570178611999140221164131