Title:Synthetic Thioamide, Benzimidazole, Quinolone and Derivatives with Carboxylic Acid and Ester Moieties: A Strategy in the Design of Antituberculosis Agents
Volume: 21
Issue: 7
Author(s): M. Ashfaq, S.S.A. Shah, T. Najam, M.M. Ahmad, R. Tabassum and G. Rivera
Affiliation:
Keywords:
Antituberculosis, benzimidazoles, carboxylic acid, design, quinolones, thioamides.
Abstract: Synthetic heterocyclic compounds have remarkable potential activity against diseases; thioamides, benzimidazoles,
quinolones and derivatives with carboxylic acid and esters moieties have shown excellent activity against Mycobacterium
tuberculosis. We reviewed antituberculosis activities of above compounds with reference to half maximal inhibitory
concentration, minimum inhibitory concentration and structural-activity relationship which clearly indicate that electron-
withdrawing groups are the main inducers of antimycobacterium activity. Comparison between clinically used drugs
and new synthetic derivatives showed recent advances made in the last decade.
