Generic placeholder image

Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis and in vivo Antihyperlipidemic Potential of Novel Substituted Thieno[3,2-d]pyrimidines

Author(s): Riyaj Shaukat Tamboli, Rakesh Devidas Amrutkar, Kishor Sanchlal Jain and Muthu Kumaradoss Kathiravan

Volume 10, Issue 9, 2013

Page: [906 - 915] Pages: 10

DOI: 10.2174/15701808113109990019

Price: $65

conference banner
Abstract

A novel series of substituted thieno[3,2-d]pyrimidin-4(3H)ones 7-22 has been synthesized and evaluated for in vivo antihyperlipidemic activity using Triton WR 1339. Out of the 16 compounds synthesized and tested, 8 compounds have shown significant effect on total lipid profile. These compounds are several times more potent than gemfibrozil, the standard drug used for comparison. The superior activity of compounds 16 and 19 may be because of their esterase mediated metabolism into active metabolites. These compounds may serve to be ideal leads to provide newer antihyperlipidemic agents.

Keywords: Antihyperlipidemic agents, Gemfibrozil, Lipid profile, Synthesis, Thieno[3, 2-d]pyrimidines, Vitamin B3.


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy