Title:Standard and Emerging Treatment Options for Diabetic Neuropathy
Volume: 20
Issue: 22
Author(s): Nicholas Tentolouris, Kleopatra Alexiadou, Konstantinos Makrilakis, Stavros Liatis, Edward Jude and Andrew J. Boulton
Affiliation:
Keywords:
Diabetic neuropathy, etiologic treatment, symptomatic treatment, aldose reductase inhibitors, protein kinase-C inhibitors, antioxidants,
antidepressants, anticonvulsants.
Abstract: Diabetic neuropathy is a common complication of diabetes mellitus affecting 30-50% of patients and is a major cause for increased
costs, morbidity and mortality. Strict diabetes control prevents this complication and may restore neurologic deficits in the early
stages. Several efforts have been undertaken to alter the natural history of this complication, including the use of aldose reductase and
protein kinase-C inhibitors, as well as antioxidants. Available data so far do not support the use of aldose reductase inhibitors due to safety
issues and efficacy. Protein kinase-C inhibitors have provided encouraging initial results but their development has been halted. Antioxidants,
like a-lipoic acid, improve some neurological deficits and painful symptoms. There are effective and safe medications such as
anticonvulsants, antidepressants and opioids for the management of patients with painful symptoms. In this revew we present standard
and emerging treatment modalities for the etiologic and symptomatic treatment of diabetic neuropathy.
