Title:Radiolabeled Probes Targeting G-Protein-Coupled Receptors for Personalized Medicine
Volume: 20
Issue: 14
Author(s): John Buscombe
Affiliation:
Keywords:
Bombesin, Chemokines, G Protein Coupled Receptors, Inflammation, Imaging, Personalized medicine, Somatostatin Receptors,
Targeted Therapy.
Abstract: The G-protein coupled receptor system is involved in a range of cell types and actions and as such has a universal potential in
identifying cell functions.
The most widely explored system is that of the somatostatin receptors which has been exploited for both imaging and therapy. However,
even with this fairly simple system, variation is seen in the behaviour of cells between patients and within different cell population within
the patient.
Newer work will exploit different ligands in a wider range of both tumour types and non-oncological processes such as inflammation.
