Title:Pathological Gambling: Update on Decision Making and Neuro-functional Studies in Clinical Samples
Volume: 20
Issue: 25
Author(s): Sophia Achab, Laurent Karila and Yasser Khazaal
Affiliation:
Keywords:
Pathological gambling, decision making, fMRI, reward.
Abstract: Given the importance and the burden of pathological gambling (PG) and its effect on gamblers and their relatives, better
comprehension of the phenomena involved in its development and persistence is needed. The present paper describes the previous 5 years
of studies on decision making and magnetic resonance imaging in people with PG. Twenty-six studies (456 participants with PG) were
included. Perseveration in monetary tasks was associated with PG despite intact executive planning abilities. PG was linked with impairment
in decision making under uncertainty. Hyperactivation of the reward pathway was repeatedly found. PG was also linked with neural
hyperactivation of the reward pathway during high-risk conditions and hypoactivation in low-risk conditions. Furthermore, in PG, near
misses activated the brain regions related to wins. Numerous similarities were found between PG and substance use disorders, highlighting
the scientific basis of the recent reclassification of PG in the spectrum of addictive disorders.
