Title:Clinical Determinants of Cognition Levels in French Cocaine Addicted Patients
Volume: 20
Issue: 25
Author(s): Michael Szprync, Michel Reynaud, Nadege Bordas and Laurent Karila
Affiliation:
Keywords:
Cocaine, cognition, memory, neuropsychological, inhibitory control, attention, executive function.
Abstract: Cocaine has become a public health problem. Several studies have shown that cocaine addiction is associated with multiple
cognitive damages, such as memory, inhibitory control, attention and executive functions. A French cohort of cocaine addicted patients
was divided into two groups: CCU (Current cocaine users) and abstainers. Their cognitive abilities were compared to a control group and
associations with clinical determinants were assessed. The CCU group and the abstainers had episodic memory, working memory and inhibitory
control disabilities compared to the control group. Both the CCU and the abstainers group had the same cognitive abilities but
their clinical determinants for these cognitive abilities differed. In the CCU group, exposure to cocaine seemed to have a negative impact
on cognition especially inhibitory control, memory and impulsivity. In the abstainers group, craving and depression impeded cognition.
