Title:Strategies to Overcome Drug Resistance of Receptor Tyrosine Kinaseaddicted Cancer Cells
Volume: 21
Issue: 14
Author(s): Flavio Maina
Affiliation:
Keywords:
RTK-addiction, oncogenic RTKs, RTK anticancer agents, mechanism of drug action, resistance mechanisms, cell
plasticity.
Abstract: The use of agents capable of impairing RTK function is gaining prominence for their effectiveness against the
tumorigenic program driven by oncogenic RTK activity in a wide range of cancer cells. Having this valuable resource in
hand for molecularly targeted anticancer therapies, it is mandatory to understand how to use these agents properly for
combined treatments in order to maximize clinical efficacy. The remarkable plasticity and adaptation of cancer cells
should also be taken into account, since this leads to the acquisition of “resistance” during treatment. By revisiting mechanisms
of drug resistance found in cancer cells and by intercalating new emerging concepts on RTK signaling coming from
cancer genome studies, this review discusses strategies aimed to enhance the effectiveness of RTK blocking agents and
overcome resistance to treatment.
