Title:DNA Demethylation: Where Genetics Meets Epigenetics
Volume: 20
Issue: 11
Author(s): Xiaofei Zhang, Rongguo Fu, Jie Yu and Xiaosheng Wu
Affiliation:
Keywords:
DNA methylation, DNA demethylation, stem cell reprogramming, AID, TET2, IDH1, DNMT3A, 5hmC.
Abstract: Epigenetic regulation is essential to the well-being of developing as well as developed cells by providing tissue-specific gene
expression. DNA methylation on cytosine nucleotides is one of the core elements of epigenetic machinery, and stable DNA methylation
patterns are maintained by properly regulated DNA methylation and DNA demethylation. DNA methylation has been studied extensively
in the past 15 years, while the DNA demethylation process has largely been unknown. In this review, we briefly survey recent advances
on DNA methylation/demethylation axis with special emphasis on the aspects of DNA demethylation.
