Title:The Renin-angiotensin System as a Target of Novel Anticancer Therapy
Volume: 19
Issue: 40
Author(s): Katarzyna Regulska, Beata Stanisz and Milosz Regulski
Affiliation:
Keywords:
The renin-angiotensin system, cancer therapy, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, transduction
mechanisms.
Abstract: The role of the renin-angiotensin system (RAS) in the development of various malignancies has recently been extensively examined
and, since it has been shown to significantly influence many aspect of cancer initiation and progression, the idea of RAS-targeted
anticancer therapy has arisen. This article reviews the mechanisms underlying RAS-induced physiological and pathological responses related
to cancer biology, including tumor growth, cell proliferation, apoptosis, angiogenesis, inflammation, and protein degradation, emphasizing
the associated cellular transduction schemes activated by main RAS effectors. Also the dual nature of RAS-dependent effects,
resulting from its complex physiology has been commented. Finally, based on the available data from clinical trials and experimental
studies, the possibilities of the introduction of RAS-modulating drugs into standard clinical practice in oncology have been discussed
with the focus on both, positive and negative effects associated with the administration of various classes of pharmaceuticals to cancer
patients.
