Title:Interaction of Anthocyanins with Drug-metabolizing and Antioxidant Enzymes
Volume: 20
Issue: 37
Author(s): H. Bártíková, L. Skálová, J. Drsata and I. Bousova
Affiliation:
Keywords:
Anthocyanins, anthocyanin-drug interactions, antioxidant enzymes, chemoprevention, drug-metabolizing enzymes,
modulation of enzymatic activity, transporters.
Abstract: Anthocyanins are generally considered to be the largest and the most important group of water-soluble pigments
in plants. They are widely consumed by humans as natural compounds of vegetables, fruits, and red wine. Anthocyanins
as well as other flavonoids show protective qualities against variety of pathologies, including cardiovascular diseases,
cancer, diabetes mellitus, neurodegeneration, inflammation, viral infections, and obesity. Many healthy properties
of anthocyanins are related to their antioxidant potency. Broad evidence of beneficial effects of anthocyanins on human
health has led to their increasing popularity in the form of food supplements and nutraceuticals. As the nutraceuticals contain
concentrated bioactive agents, consumed doses exceed those that could be obtained from food. Therefore, apart from
anticipated improvement of human health it is essential to have in mind possible unexpected effects of anthocyanins. Interaction
of these compounds with drug-metabolizing enzymes and transporters may affect the fate of co-administered
drugs and thus exert pharmacological consequences. On the other hand, the modulation of certain drug-metabolizing and
antioxidant enzymes by anthocyanins can contribute to chemoprotection and antioxidant defense of organisms. The present
review summarizes anthocyanin properties with emphasis on the antioxidant capacity and deals with the potential of
anthocyanins to modulate phase I and II drug-metabolizing enzymes, transporters and antioxidant enzymes. The undesirable
and/or beneficial outcomes of possible interactions of anthocyanins with drugs or industrial pollutants are also discussed.
