Title:Oxidative stress in carcinogenesis: new synthetic compounds with dual effects upon free radicals and cancer.
Volume: 20
Issue: 36
Author(s): Betul Tekiner-Gulbas, Andrew D. Westwell and Sibel Suzen
Affiliation:
Keywords:
Antioxidant, anticancer, carcinogenesis, DNA mutation, drug development, oxidative stress.
Abstract: DNA mutation is a very important step in carcinogenesis and elevated levels of oxidative DNA damage have
been monitored in a variety of tumors. The discovery of the role of free radicals in cancer has led to a new medical approach.
Minimizing oxidative damage may be a significant advance in the prevention or treatment of these diseases, since
antioxidants are able to stop the free-radical formation and prevent oxidizing chain reactions. These findings have generated
great interest in therapeutic antioxidant-based cancer drug development. The design and development of synthetic
compounds, able to scavenge free radicals, could present a significant therapeutic advance, in particular for treating pathological
conditions such as cancer. This article will outline the state of the research on the relationship between antioxidant
therapy and cancer, describing the new synthetic antioxidant molecules that have anticancer activities. Investigations and
association between dietary antioxidants, oxidative stress, and cancer will be also discussed.
