Title:BPC 157 and Blood Vessels
Volume: 20
Issue: 7
Author(s): Sven Seiwerth, Luka Brcic, Lovorka Batelja Vuletic, Danijela Kolenc, Gorana Aralica, Marija Misic, Anita Zenko, Domagoj Drmic, Rudolf Rucman and Predrag Sikiric
Affiliation:
Keywords:
Vasculogenesis, embryonic/fetal, primary development; Angiogenesis, healing tumors, adults; Arteriogenesis, hypoxia/occlusion
induced, secondary, adults; Blood vessel leakage, pressure induced, minimal vessel wall damage induced, edema; Blood vessel leakage, vessel
wall damage induced, exudate; Blood vessel obstruction, vessel wall damage, thrombosis.
Abstract: This review focuses on the described effects of BPC 157 on blood vessels after different types of damage, and elucidate by investigating
different aspects of vascular response to injury (endothelium damage, clotting, thrombosis, vasoconstriction, vasodilatation,
vasculoneogenesis and edema formation) especially in connection to the healing processes. In this respect, BPC 157 was concluded to be
the most potent angiomodulatory agent, acting through different vasoactive pathways and systems (e.g. NO, VEGF, FAK) and leading to
optimization of the vascular response followed, as it has to be expected, by optimization of the healing process.
Formation of new blood vessels involves two main, partly overlapping mechanisms, angiogenesis and vasculogenesis. The additional
mechanism of arteriogenesis is involved in the formation of collaterals. In conjunction with blood vessel function, we at least have to
consider leakage of fluid/proteins/plasma, resulting in edema/exudate formation as well as thrombogenesis. Blood vessels are also
strongly involved in tumor biology. In this aspect, we have neoangiogenesis resulting in pathological vascularization, vascular invasion
resulting in release of metastatic cells and the phenomenon of homing resulting in formation of secondary tumors – metastases.
