![conference banner](/images/conference-banner.jpeg)
Abstract
Agelasines, asmarines and related compounds are natural products with a hybrid terpene-purine structure isolated from numerous genera of sponges (Agela sp, Raspailia sp). Nuttingins and malonganenones are tetraprenylated purine alkaloids from gordonian (Eplexura sp, Leptogorgia sp). Some of these alkaloids displayed broad spectrum activity including cytotoxic activity against several cancer cells. The review summarizes the synthesis of mono- or bi-cyclic diterpenoids usually having a 9-methyladenine moiety.
Keywords: Alkyl purine, terpene purine, agelasine, ageline, ageloxime, gelasine, agelasimine, asmarine, nuttingin, malonganenone.
Current Medicinal Chemistry
Title:Synthetic Approaches Towards the Marine Alkyl Purines
Volume: 20 Issue: 22
Author(s): M. Gordaliza and P. G. Baraldi
Affiliation:
Keywords: Alkyl purine, terpene purine, agelasine, ageline, ageloxime, gelasine, agelasimine, asmarine, nuttingin, malonganenone.
Abstract: Agelasines, asmarines and related compounds are natural products with a hybrid terpene-purine structure isolated from numerous genera of sponges (Agela sp, Raspailia sp). Nuttingins and malonganenones are tetraprenylated purine alkaloids from gordonian (Eplexura sp, Leptogorgia sp). Some of these alkaloids displayed broad spectrum activity including cytotoxic activity against several cancer cells. The review summarizes the synthesis of mono- or bi-cyclic diterpenoids usually having a 9-methyladenine moiety.
Export Options
About this article
Cite this article as:
Gordaliza M. and Baraldi G. P., Synthetic Approaches Towards the Marine Alkyl Purines, Current Medicinal Chemistry 2013; 20 (22) . https://dx.doi.org/10.2174/0929867311320220005
DOI https://dx.doi.org/10.2174/0929867311320220005 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the Treatment of Chronic Inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
![Wayfinder Image](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Interstitial Lung Disease in Idiopathic Inflammatory Myopathy
Current Rheumatology Reviews Synthesis of 3-phenyl-4-phenylvinyl Benzopyranones and the Corresponding 2,2-dimethyl-benzopyrans with Structural Similarity to Estradiol, as Estrogen Receptor Ligands
Medicinal Chemistry The Effect of Some Symptoms and Features During the Infection Period on the Level of Anxiety and Depression of Adults after Recovery from COVID-19
Current Psychiatry Research and Reviews Recent Advances in the Development of Selective CB2 Agonists as Promising Anti-Inflammatory Agents
Current Medicinal Chemistry Phytotherapic Drugs for COVID-19 Treatment: A Scoping Review
Current Pharmaceutical Design Antidiabetic Drugs and their Potential Use in COVID-19: A Mechanistic Approach
Endocrine, Metabolic & Immune Disorders - Drug Targets cGMP-Dependent Protein Kinase in Regulation of the Pulmonary Circulation
Current Respiratory Medicine Reviews Millennium Nutrient N,N-Dimethylglycine (DMG) and its Effectiveness in Autism Spectrum Disorders
Current Medicinal Chemistry Advances in the Treatment of Chronic Myeloid Leukemia
Recent Patents on Anti-Cancer Drug Discovery Purine-Scaffold Hsp90 Inhibitors
Current Topics in Medicinal Chemistry Long-Term Outcome of Infants Born Late Preterm
Current Pediatric Reviews New Therapeutic Approaches Targeted at the Late Stages of the HIV-1 Replication Cycle
Current Medicinal Chemistry COVID-19 in Patients with Systemic Inflammatory Diseases: Impact on Disease Activity
Current Rheumatology Reviews Drug Design Strategies for the Discovery of Novel Anticonvulsants Concerned with Four Site Binding Pharmacophoric Model Studies
Central Nervous System Agents in Medicinal Chemistry Synthesis and Inhibitory Effects of Some Novel 1,3-diarylprop-2-en-1-one Analogues in Foxp3 Expression: A Novel Class of Anti-cancer Candidates
Medicinal Chemistry Medicinal Chemistry of Alternative Therapeutics: Novelty and Hopes with Genus Ammannia
Current Topics in Medicinal Chemistry Medicinal Attributes of Imidazo[1,2-a]pyridine Derivatives: An Update
Current Topics in Medicinal Chemistry p53-Induced Apoptosis and Inhibitors of p53
Current Medicinal Chemistry Natural Products as Potential Agents against SARS-CoV and SARSCoV- 2
Current Medicinal Chemistry α-Fluorinated Ethers as “Exotic” Entity in Medicinal Chemistry
Mini-Reviews in Medicinal Chemistry