Title:Developments in Synthesis of the Anti-inflammatory Drug, Celecoxib: A Review
Volume: 7
Issue: 2
Author(s): Vinod Kumar, Kamalneet Kaur, Girish K. Gupta, Akhilesh K. Gupta and Sunil Kumar
Affiliation:
Keywords:
Anticancer activity, anti-inflammatory, Celecoxib, COX-2 inhibitor, 4-methylacetophenone, 4-
sulphonamidophenyl hydrazine hydrochloride, 4, 4, 4-trifluoro-1-[4-(methylphenyl)] butane-1, 3-dione.
Abstract: Celecoxib, a tricyclic compound having pyrazole ring exhibits an excellent level of antiinflammatory action
against COX-2 enzymes and some of its analogs act as anticancer and antibacterial agents. Various efficient routes and
different improved processes for the synthesis of this drug have already been disclosed in the literature. However, there is
a need for further developments in the present scenario of achieving cost effective synthetic technologies to celecoxib
with high purity accompanied by excellent yield. Therefore, an effort has been made to summarize briefly the different
methods of preparation of Celecoxib with their advantages or disadvantages that have been reported in various patents up
to 2013. The present review would be beneficial for scientific community for further developments in the synthetic methodologies
for Celecoxib and to explore some novel celecoxib based biologically active agents.
