Synthesis and Biological Evaluation of Piperazinyl-2-(Benzo)thiophen/- furan-2-yl-acetonitriles as Strecker Reaction Products

Title:Synthesis and Biological Evaluation of Piperazinyl-2-(Benzo)thiophen/- furan-2-yl-acetonitriles as Strecker Reaction Products

Volume: 10 Issue: 5

Author(s): Rahul V. Patel, Jigar K. Patel, Shivraj H. Nile and Se Won Park

Affiliation:

Keywords: Thiophehe, Furan, piperazine, Indium powder, Catalyst, Antimicrobial activity

Abstract: Single step construction of heterocyclic α-aminonitriles has been carried out using Indium Powder as catalyst in water medium via Strecker reaction methodology. The multicomponent reaction products were examined for their inhibitory potential against two Gram-positive bacteria (S. aureus and B. cereus), three Gram-negative bacteria (E. coli, P. aeruginosa and K. pneumoniae) and two fungal species (A. niger and C. albicans). The biological screening identified that the some compounds were found to possess promising antimicrobial (6.25-50 μg/mL of MIC) potential. A structure– activity relationship (SAR) study was explored to facilitate further development of this new class of compounds. The structural assignments of the new products were done on the basis of IR, ¹H NMR, ¹³C NMR spectroscopy and elemental analysis.

Cite this article as:

V. Patel Rahul, K. Patel Jigar, H. Nile Shivraj and Won Park Se, Synthesis and Biological Evaluation of Piperazinyl-2-(Benzo)thiophen/- furan-2-yl-acetonitriles as Strecker Reaction Products, Letters in Drug Design & Discovery 2013; 10 (5) . https://dx.doi.org/10.2174/1570180811310050014

DOI https://dx.doi.org/10.2174/1570180811310050014	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X