Title:Synthesis and Biological Evaluation of some Amide Derivatives Bearing Benzothiazole and Piperidine Moieties as Antimicrobial Agents
Volume: 10
Issue: 5
Author(s): Mehlika Dilek Altintop, Ahmet Ozdemir, Zafer Asim Kaplancikli, Gulhan Turan-Zitouni, Gokalp Iscan and Gulsen Akalin Ciftci
Affiliation:
Keywords:
Amide, Benzothiazole, Piperidine, Antimicrobial activity, Cytotoxicity
Abstract: In this study, N-(benzothiazol-2-yl)-2-(piperidin-1-yl)acetamide derivatives (1-24) were obtained by the reaction
of 2-chloro-N-(benzothiazole-2-yl)acetamides with piperidine derivatives. The structures of the compounds were elucidated
by 1H-NMR and mass spectral data and elemental analysis. The compounds were screened for their antimicrobial
activities against pathogenic bacteria and Candida species. The compounds were also investigated for their cytotoxic
properties using MTT assay. The microbiological results revealed that the compounds were more effective against fungi
than bacteria. Among Candida species, C. utilis was the most susceptible fungus to compounds 7 and 11. It is apparent
that 2,6-dimethylpiperidine group and chloro and methyl substituents on benzothiazole ring have an important impact on
anticandidal activity. MTT assay indicated that the effective doses of these derivatives were lower than their cytotoxic
doses.
