Title: Targeting JAK3 Tyrosine Kinase-Linked Signal Transduction Pathways with Rationally-Designed Inhibitors
Volume: 7
Issue: 6
Author(s): Fatih M. Uckun, Alexei Vassilev, Ilker Dibirdik and Heather Tibbles
Affiliation:
Keywords:
Rational Drug Design, Tyrosine Kinases, Inhibitors, JAK3
Abstract: Inhibitors of Janus Kinase 3 (JAK3) show potential as a new class of apoptosis-inducing anti-cancer drugs. In addition, JAK3 inhibitors may also be useful as immunosuppressive agents. Rationally designed selective inhibitors of JAK3 such as JANEX-1, that do not inhibit other Janus kinases have recently undergone extensive preclinical testing that revealed a favorable pharmacodynamic profile. Here we discuss the clinical potential of targeting JAK3-linked signal transduction pathways with small molecule inhibitors such as JANEX-1.
