Abstract
Recent advances in genomic drug development and high-throughput technologies, such as combinatorial chemistry, high throughput screening and in silico screening, are making it easier to screen compounds with pharmaceutical activity. Drugs developed by genomic and throughput technologies traverse the epithelial and endothelial membranes. Although the paracellular pathway is a potent drug delivery route for these drugs, few strategies for their delivery have been developed because tight junctions (TJs), which exist between adjacent cells, strictly regulate the movement of solutes. Recent progress in biology of TJs has provided new insights into the biochemical and functional structure of TJs, and into the roles that occludin, claudins and tricellulin play in regulating TJ barriers. Novel strategies based on TJ-components for delivering drugs through the paracellular pathway have been developed. In this review, we discuss drug delivery through the paracellular route within the context of biology of TJs, as well as future directions of TJ-component-based drug delivery systems.
Keywords: Tight junction, claudin, drug delivery, paracellular route
Current Medicinal Chemistry
Title: Tight Junction Modulators: Promising Candidates for Drug Delivery
Volume: 14 Issue: 23
Author(s): M. Kondoh and K. Yagi
Affiliation:
Keywords: Tight junction, claudin, drug delivery, paracellular route
Abstract: Recent advances in genomic drug development and high-throughput technologies, such as combinatorial chemistry, high throughput screening and in silico screening, are making it easier to screen compounds with pharmaceutical activity. Drugs developed by genomic and throughput technologies traverse the epithelial and endothelial membranes. Although the paracellular pathway is a potent drug delivery route for these drugs, few strategies for their delivery have been developed because tight junctions (TJs), which exist between adjacent cells, strictly regulate the movement of solutes. Recent progress in biology of TJs has provided new insights into the biochemical and functional structure of TJs, and into the roles that occludin, claudins and tricellulin play in regulating TJ barriers. Novel strategies based on TJ-components for delivering drugs through the paracellular pathway have been developed. In this review, we discuss drug delivery through the paracellular route within the context of biology of TJs, as well as future directions of TJ-component-based drug delivery systems.
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Cite this article as:
Kondoh M. and Yagi K., Tight Junction Modulators: Promising Candidates for Drug Delivery, Current Medicinal Chemistry 2007; 14 (23) . https://dx.doi.org/10.2174/092986707782023640
DOI https://dx.doi.org/10.2174/092986707782023640 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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