Title:Obesity-Driven Inflammation and Colorectal Cancer
Volume: 19
Issue: 34
Author(s): N. Vazzana, S. Riondino, V. Toto, F. Guadagni, M. Roselli, G. Davì and P. Ferroni
Affiliation:
Keywords:
Adipokines, colorectal cancer, inflammation, insulin resistance, visceral obesity, white adipose tissue, gut microbiota, liver inflammation,
free fatty acid, non-alcoholic steatohepatitis
Abstract: Visceral obesity is characterized by increased risk of cardiovascular disease as well as higher incidence of malignancies, including
colorectal cancer (CRC), although the mechanisms linking excess adiposity with cancer are only partly characterized. Visceral
obesity is currently acknowledged as a chronic inflammatory disorder and a growing body of evidence demonstrates the interconnections
between obesity-related secretion pattern of adipo/cytokines and CRC. Specific molecules derived from the visceral adipose tissue
(VAT), including adiponectin, leptin and resistin, are able to establish a positive feedback loop, thus increasing the proinflammatory and
insulin resistant state and promoting tumorigenesis. Interestingly, these molecules have emerged as novel prognostic factors and therapeutic
targets. This review will focus on current molecular and clinical evidence linking VAT-related inflammation to CRC initiation and
progression, and summarize the role of dietary factors and lifestyle interventions aimed at promoting weight control and physical activity
on CRC prevention and prognosis.
