Title:Flavonoids Acting on DNA Topoisomerases: Recent Advances and Future Perspectives in Cancer Therapy
Volume: 19
Issue: 31
Author(s): P. Russo, A. Del Bufalo and A. Cesario
Affiliation:
Keywords:
Cell death, clinical trials, DNA topoisomerases, DNA topoisomerases poisoning, drug discovery and development, flavonoids, phenoxodiol, systems Biology, therapeutic agents, Luteolin
Abstract: Flavonoids, secondary metabolites ubiquitously produced in the plant kingdom, are low molecular weight polyphenolic molecules.
They are characterized by variable chemical structures and show a vast array of biological activities (i.e... antiviral, antiinflammatory,
antitumor, antimicrobial, estrogenic, antiestrogenic, antioxidant, mutagenic and antimutagenic) targeting different pathways.
Some of these compounds such as Genistein, Daidzein or its synthetic derivative Phenoxodiol as well as Luteolin and Quercetin
are able to inhibit DNA topoisomerases. This review discusses that Flavonoids targeting DNA topoisomerases may lead to novel drug
development with anticancer potential.