Title:Differentiated Thyroid Carcinoma and Intestinal Polyposis Syndromes
Volume: 12
Issue: 4
Author(s): Vincenzo Triggiani, Vito Angelo Giagulli, Angela Tafaro, Francesco Resta, Carlo Sabba, Brunella Licchelli and Edoardo Guastamacchia
Affiliation:
Keywords:
Cowden’s syndrome, differentiated thyroid carcinoma, familial adenomatous polyposis, follicular thyroid
carcinoma, intestinal polyposis syndromes, papillary thyroid carcinoma, peutz-jeghers syndrome, multiple hamartoma syndrome, colorectal carcinoma, Ret-PTC rearrangements, Associated non-cutaneous malignancies, Prophylactic thyroidectomy.
Abstract: Familial Adenomatous Polyposis, Cowden’s Syndrome, and Peutz-Jeghers Syndrome are well known as
Intestinal Polyposis Syndromes, inherited conditions characterized by the development of polyps of the gastro-intestinal
tract in association with extra-intestinal manifestations, in particular malignant tumors at different sites. Thyroid
carcinoma is sometimes a part of the clinical picture of these syndromes. The aim of this paper is to review the literature
dealing with the association between differentiated thyroid carcinomas and Intestinal Polyposis Syndromes in order to
point out peculiar aspects, providing suggestions for the screening and the management of thyroid tumors in these
patients.
