Title:Personalized Therapies in Pediatric Inflammatory and Autoimmune Diseases
Volume: 18
Issue: 35
Author(s): Gabriele Stocco, Sara De Iudicibus, Raffaella Franca, Riccardo Addobbati and Giuliana Decorti
Affiliation:
Keywords:
Pediatric inflammatory bowel disease, juvenile rheumatoid arthritis, personalized therapy, pharmacogenetics, pharmacokinetics,
pharmacodynamics
Abstract: Pediatric inflammatory and autoimmune diseases are a wide array of systemic or organ-specific conditions, characterized by
an exaggerated immune reactivity, which generally occurs in immunogenetically predisposed children. Among the most important ones,
in terms of their diffusion and morbidity in the population worldwide, pediatric inflammatory bowel disease (IBD) and juvenile rheumatoid
arthritis (JRA) have to be considered. The aim of personalized therapy is to give to each patient the most appropriate drug and dose
regimen, in order to maximize treatment response and reduce the risk of adverse events. In general, several therapeutic options exist for
pediatric inflammatory and autoimmune conditions, therefore the perspective of pharmacological tools that allow identification of patients
with increased risk of treatment issues related to a particular medication, in terms of lack of efficacy or increased probability of adverse
events, is particularly desirable and promising. The present review will be focused on the personalized therapy approaches already
available or in development for pediatric patients with IBD or JRA, comprising pharmacokinetic, pharmacodynamic and pharmacogenetic
assays.
