Title:TGF-Beta Inihibitor-loaded Polyelectrolyte Multilayers Capsules for Sustained Targeting of Hepatocarcinoma Cells
Volume: 18
Issue: 27
Author(s): Viviana Vergaro, Francesca Baldassarre, Flavia De Santis, Giuseppe Ciccarella, Gianluigi Giannelli and Stefano Leporatti
Affiliation:
Keywords:
Polyelectrolytes, capsules, HCC, TGF beta- inhibitor, targeted drug delivery, growth factor inhibitor, epatocarcinoma, polyelectrolyte multilayers capsules (PMCs), cancer therapy, Bevacizumab.
Abstract: In this review we will report on recent advanced in polyelectrolyte capsules for targeted drug delivery (eg of growth factor inhibitor)
against epatocarcinoma. Degradable polyelectrolyte multilayers capsules (PMCs) are of particular interest for cancer therapy
since under physiological conditions they can be enzymatically degraded upon cell interaction. Small bioactive molecules such as TGFBeta
inhibitors can be incorporated inside them. Nano-to-microscale delivery systems can enhance efficacy at single cell level for targeted
therapy. Layer-by-layer (LbL) self-assembled capsules are novel carriers maximizing drug administration and improving antimetastatic
activity of TGF-Beta inhibitors in Hepatocellular Carcinoma (HCC).
