Title:BMPS and Liver: More Questions than Answers
Volume: 18
Issue: 27
Author(s): Blanca Herrera, Aranzazu Sanchez and Isabel Fabregat
Affiliation:
Keywords:
BMP, liver, signaling, fibrosis, hepatocellular carcinoma, development, iron homeostasis, TGF-β, bone homeostasis, tumorigenic actions.
Abstract: Bone morphogenetic proteins (BMPs) belong to the TGF-β superfamily and were first discovered as potent bone homeostasis
regulators for their ability to induce endochondral bone formation, ectopic bone formation and fracture repair. A preeminent role of BMP
signaling in developmental control of cell type specification, differentiation and organogenesis is also well established. More recently, a
role for BMPs in adult tissue homeostasis has started being revealed. Thus, new studies show that BMPs regulate many cellular processes
such as proliferation, apoptosis, differentiation and migration in many tissues and organs. As a consequence, dysregulation of BMP activity
can have pathological consequences, and there is mounting evidence for the involvement of BMPs in different human diseases. In this
review, we have focused on summarizing the present knowledge on the relevance of BMPs in liver physiology and pathophysiology,
from the well-recognized role in liver development to the emerging contribution to the function and dysfunction of the adult liver. While
no doubts seem to rise about the regulatory activities of BMPs on metabolic pathways in the liver, potential pro- and anti-fibrogenic and
tumorigenic actions will likely be a matter of debate during coming years. Collectively, the work here presented provides the basis to
consider BMPs as potential targets of intervention in liver diseases.
