Title:Implantable (Bio)Polymer Coated Titanium Scaffolds: A Review
Volume: 18
Issue: 18
Author(s): Els Vanderleyden, Steven Mullens, Jan Luyten and Peter Dubruel
Affiliation:
Keywords:
Titanium, surface modification, scaffolds, (bio)polymer, bone tissue engineering, organic modifications, physical adsorption, physical incorporation, covalent immobilisation, three-dimensional titanium scaffolds
Abstract: In the current review we aim to give an overview of the state of the art of the research on (bio)polymer functionalised titanium
implants for bone tissue engineering applications. After a short introduction on bone tissue engineering and the requirements the applied
materials have to meet, an extensive discussion on titanium in bone tissue engineering will be given. Starting with a short description of
both the titanium bulk and surface properties, the requirement for surface modified titanium will be highlighted. The discussion will encompass
inorganic and organic chemical modifications and a combination thereof with a focus on the organic modifications. Within the
latter type of modification, physical adsorption, physical incorporation and covalent immobilisation will be compared. In the final part of
the review an overview will be given of the fabrication and characterisation of three-dimensional titanium scaffolds.
