Abstract
Growing demands on a suitable formulation method that ensures the stability of the active compound coupled with the limitations of current methods (milling, lyophilization, spray drying, and freeze spray drying) has brought wide attention to supercritical fluid (SCF) technology. Advantages of using the SCF technology comprise its high abilities, adaptability in providing alternative processing methods, high compressibility and diffusivity of the supercritical fluid, capability as an alternative for conventional organic solvents, and the option to attain different processing parameters which would be otherwise difficult to conduct with traditional methods. This review proposes to present an up-to-date outlook on dry powder pulmonary formulations of macromolecules using SCF technology.
Keywords: Dry powder, super critical fluid, protein, microparticles, peptide, macromolecules, SCF, Anaemia, Encapsulation of Insulin, POWDER INHALATION, inhalation
Drug Delivery Letters
Title: Recent Advances Using Supercritical Fluid Techniques for Pulmonary Administration of Macromolecules via Dry Powder Formulations
Volume: 1 Issue: 2
Author(s): Iman M. Al-fagih, Fars K. Alanazi, Gillian A. Hutcheon and Imran Y. Saleem
Affiliation:
Keywords: Dry powder, super critical fluid, protein, microparticles, peptide, macromolecules, SCF, Anaemia, Encapsulation of Insulin, POWDER INHALATION, inhalation
Abstract: Growing demands on a suitable formulation method that ensures the stability of the active compound coupled with the limitations of current methods (milling, lyophilization, spray drying, and freeze spray drying) has brought wide attention to supercritical fluid (SCF) technology. Advantages of using the SCF technology comprise its high abilities, adaptability in providing alternative processing methods, high compressibility and diffusivity of the supercritical fluid, capability as an alternative for conventional organic solvents, and the option to attain different processing parameters which would be otherwise difficult to conduct with traditional methods. This review proposes to present an up-to-date outlook on dry powder pulmonary formulations of macromolecules using SCF technology.
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Cite this article as:
M. Al-fagih Iman, K. Alanazi Fars, A. Hutcheon Gillian and Y. Saleem Imran, Recent Advances Using Supercritical Fluid Techniques for Pulmonary Administration of Macromolecules via Dry Powder Formulations, Drug Delivery Letters 2011; 1 (2) . https://dx.doi.org/10.2174/2210304x11101020128
DOI https://dx.doi.org/10.2174/2210304x11101020128 |
Print ISSN 2210-3031 |
Publisher Name Bentham Science Publisher |
Online ISSN 2210-304X |
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