Highly Efficient Synthesis of β-Amino Ketones via Direct Mannich-type Reaction Catalyzed by Acidic Ionic Liquid

Title: Highly Efficient Synthesis of β-Amino Ketones via Direct Mannich-type Reaction Catalyzed by Acidic Ionic Liquid

Volume: 8 Issue: 6

Author(s): Dong-Nuan Zhang, Ji-Tai Li, Ya-Li Song and Guo-Feng Chen

Affiliation:

Keywords: Mannich-type reaction, β-amino ketones, synthsis, ionic liquid, catalysis, cyclohexanone, polystyrene-supported, acetophenone, non-inflammability, dodecylbenzenesulfonic

Abstract: [MPSIm]+CF3COO- ionic liquid is an efficient green catalyst for the one-pot, three-component Mannich-type reaction of aromatic aldehydes, aromatic amines and cyclohexanone. The reaction was completed within 5-60 min to give the corresponding β-amino ketones in 82-98% yield at room temperature. The catalyst can be recycled at least four times without significant decrease in activity.

Cite this article as:

Zhang Dong-Nuan, Li Ji-Tai, Song Ya-Li and Chen Guo-Feng, Highly Efficient Synthesis of β-Amino Ketones via Direct Mannich-type Reaction Catalyzed by Acidic Ionic Liquid, Letters in Organic Chemistry 2011; 8 (6) . https://dx.doi.org/10.2174/157017811796064458